Molecular Diagnostics

At our diagnostic lab, we offer comprehensive molecular pathology services designed to provide precise and timely diagnostic information. It is one of the most dynamic and transformative departments with interplay of genomic knowledge, laboratory medicine and cutting-edge technology. Molecular laboratory menu has steadily grown in all applications ranging from infectious disease, genetic, and oncology testing. This varied portfolio is realized by diverse instruments, facilitating tests for solid tumors and hematological malignancies. 

Our Services:

Infectious Disease Testing
Our molecular lab specializes in the detection and identification of infectious agents using advanced molecular techniques. We provide testing for a wide range of pathogens. Our services include:

• Pathogen screening: Rapid and accurate identification of infectious agents through Polymerase Chain Reaction (PCR), enabling early detection and appropriate treatment.
• Multiplex Assays: Simultaneous detection of multiple pathogens from a single sample, improving diagnostic efficiency.
• Viral Load Monitoring: Quantification of viral loads for conditions such as CMV, Hepatitis B and C, aiding in disease management and monitoring treatment efficacy.
• Genotyping and Resistance Testing: Identification of specific pathogen strains (HPV, MTB) and their resistance profiles to guide targeted therapy.

Oncology Testing
Our molecular pathology services extend to comprehensive oncology testing, providing critical insights into cancer diagnosis, prognosis, and treatment planning. We offer a range of molecular tests for oncology, including:

•  Cancer Diagnostics: We offer molecular testing for cancer diagnosis, prognosis, and treatment selection, empowering oncologists and patients with personalized treatment options.
  •    Tests for HAEMATOLOGICAL MELIGNANCY (AML, ALL, MPN Panel) 
  •    Tests for SOLID TUMORS (EGFR, KRAS, NRAS, BRAF)
•  Genetic and Genomic Testing: Analysis of genetic mutations and alterations that drive cancer development, helping to identify targeted therapies and personalized treatment plans.

Molecular Test Offered 

INFECTIOUS DISEASES

1) Respiratory Viral Panel

• Influenza A virus (Flu A) 
• Influenza A-H1 (Flu A-H1) 
• Influenza A-H1pdm09 (Flu A-H1pdm09) 
• Influenza A-H3 (Flu A-H3) 
• Influenza B virus (Flu B) 
• Respiratory syncytial virus A (RSV A) 
• Respiratory syncytial virus B (RSV B) 
• Adenovirus 
• Enterovirus 
• Metapneumovirus
• Parainfluenza virus 1
• Parainfluenza virus 2
• Parainfluenza virus 3
• Parainfluenza virus 4
• Bordetella parapertussis
• Bordetella pertussis 
• Chlamydophila pneumoniae 
• Haemophilus influenzae 
• Legionella pneumophila 
• Mycoplasma pneumoniae 
• Streptococcus pneumoniae 

2) Meningitis Viral Panel: Detection of 12 viruses causing meningitis

• Cytomegalovirus (CMV)
• Epstein –Barr Virus (EBV)
• Herpes simplex virus type 1 
• Herpes simplex virus type 2 
• Human herpes virus 6 
• Human herpes virus 7 
• Varicella –Zoster virus
• Human adenovirus
• Human parechovirus
• Human enterovirus
• Mumps virus
• Parvovirus B19

3) Meningitis Bacterial Panel: Detection of 6 bacteria causing meningitis

• Escherichia coli K1 
• Group B Streptococcus 
• Haemophilus influenza 
• Listeria monocytogenes 
• Neisseria meningitidis 
• Streptococcus pneumoniae

4) Tropical fever Panel

• Dengue virus
• Chikungunya virus
• Salmonella Spp.
• Plasmodium Spp.
• Rickettsia Spp.
• West Nile virus
• Leptospira Spp.
• Zika virus

5) Qualitative Test for HPV High risk genotypes

•  Detection of 14 high risk HPV genotypes (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68)

6) Quantitative Test for CMV
7) Quantitative Test for HBV
8) Quantitative Test for HCV
9) Qualitative test for MTB/NTM

HAEMATOLOGICAL MALIGNANCY

1) AML Panel

• PML RARA translocation
• AML1-ETO (RUNX1-RUNX1T1)
• CBFB-MYH11 (inv (16)
• BCR ABL1 (Major (P210), minor (p190))
• FLT3 TKD (D835) & ITD
• NPM1 
• C-KIT (D816V)

2) ALL Panel

• TCF3-PBX1 (E2A-PBX1)
• ETV6-RUNX1 (TEL-AML1)
• KMT2A-AFF1 (MLL-AF4)
• KMT2A-MLLT1 (MLL-ENL)
• KMT2A-MLLT3 (MLL-AF9)
• BCR-ABL1 (Major, minor, micro)

3) MPN Panel

• BCR ABL p210, p190 & p230 transcript
• JAK2 Exon 14 Mutation (V617F)
• JAK2 Exon-12 mutations
• MPL gene Exon 10 mutations
• CALR exon 9 mutation
• CSF3R gene (T615A and T618I)

4) BCR-ABL Quantitative-IS
5) JAK-2 Exon-14 V617F Mutation detection
6) HLA B-27 by RT PCR
7) Comprehensive Myeloid Panel-NGS
8) Qualitative PCR for detection of PML-RARA

SOLID TUMORS

1)    EGFR (EX-18, 19, 20, 21) Mutation detection 
2)    NRAS Mutation Testing By Real Time Qualitative PCR
3)    KRAS Mutation Testing By Real Time Qualitative PCR
4)    BRAF